Authors
Eitan Auriel, Andreas Charidimou, M Edip Gurol, Jun Ni, Ellis S Van Etten, Sergi Martinez-Ramirez, Gregoire Boulouis, Fabrizio Piazza, Jacopo C DiFrancesco, Matthew P Frosch, Octάvio M Pontes-Neto, Ashkan Shoamanesh, Yael Reijmer, Anastasia Vashkevich, Alison M Ayres, Kristin M Schwab, Anand Viswanathan, Steven M Greenberg
Publication date
2016/2/1
Journal
JAMA neurology
Volume
73
Issue
2
Pages
197-202
Publisher
American Medical Association
Description
Importance
Cerebral amyloid angiopathy–related inflammation (CAA-ri) is an important diagnosis to reach in clinical practice because many patients with the disease respond to immunosuppressive therapy. Reliable noninvasive diagnostic criteria for CAA-ri would allow some patients to avoid the risk of brain biopsy.
Objective
To test the sensitivity and specificity of clinical and neuroimaging-based criteria for CAA-ri.
Design, Setting, and Participants
We modified the previously proposed clinicoradiological criteria and retrospectively analyzed clinical medical records and magnetic resonance imaging fluid-attenuated inversion recovery and gradient-echo scans obtained from individuals with CAA-ri and noninflammatory CAA. At 2 referral centers between October 1, 1995, and May 31, 2013, and between January 1, 2009, and December 31, 2011, participants included 17 individuals with pathologically confirmed CAA-ri …
Scholar articles
E Auriel, A Charidimou, ME Gurol, J Ni, ES Van Etten… - JAMA neurology, 2016