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METHODS

20 symptomatic children (3-14 yrs) with NLUTD and 5 asymptomatic children (controls age 5–14 yrs) participated in this prospective cohort series. Subjects were studied at a tertiary care children's hospital after natural bladder filling. NIRS changes in O2Hb and HHb were monitored transcutaneously at 10 Hz during uroflow using wireless NIRS over the detrusor. Patterns of change in chromophore concentration from permission to void (zeroed to baseline) through to uroflow end were compared.

RESULTS

Patterns of chromophore change in asymptomatic subjects had good intersubject reproducibility (increased tHb [02Hb+ HHb] following permission and upward trend of tHb during uroflow, predominantly due to elevated O2Hb). In children with NLUTD a different pattern was observed with tHb increase blunted or absent and HHb concentration greater than O2Hb; a pattern consistent with altered detrusor …