Authors
Michael M Ward, Atul Deodhar, Lianne S Gensler, Maureen Dubreuil, David Yu, Muhammad Asim Khan, Nigil Haroon, David Borenstein, Runsheng Wang, Ann Biehl, Meika A Fang, Grant Louie, Vikas Majithia, Bernard Ng, Rosemary Bigham, Michael Pianin, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Jeff Oristaglio, Amy Turner, Walter P Maksymowych, Liron Caplan
Publication date
2019/10
Source
Arthritis & rheumatology
Volume
71
Issue
10
Pages
1599-1613
Description
Objective
To update evidence‐based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA).
Methods
We conducted updated systematic literature reviews for 20 clinical questions on pharmacologic treatment addressed in the 2015 guidelines, and for 26 new questions on pharmacologic treatment, treat‐to‐target strategy, and use of imaging. New questions addressed the use of secukinumab, ixekizumab, tofacitinib, tumor necrosis factor inhibitor (TNFi) biosimilars, and biologic tapering/discontinuation, among others. We used the Grading of Recommendations, Assessment, Development and Evaluation methodology to assess the quality of evidence and formulate recommendations and required at least 70% agreement among the voting panel.
Results
Recommendations for AS and nonradiographic axial SpA are similar. TNFi are …
Scholar articles
MM Ward, A Deodhar, LS Gensler, M Dubreuil, D Yu… - Arthritis & rheumatology, 2019