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In article number 2400009, Xiucai Ye, Hao Lin, Yang Zhang, and co-workers explore the dual functionality of long non-coding RNA (lncRNA), which is symbolized as the Yin-Yang. In Chinese mythology, Nüwa, the figure of creation, is depicted playing a flute, representing the cellular mechanisms that regulate the dual functions of lncRNA. Under her feet lies a chessboard, its pieces of varying colors mirroring the Tai Chi symbol above.