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We present a constraint-based approach to computing winning strategies in two-player graph games over the state space of infinite-state programs. Such games have numerous applications in program verification and synthesis, including the synthesis of infinite-state reactive programs and branching-time verification of infinite-state programs. Our method handles games with winning conditions given by safety, reachability, and general Linear Temporal Logic (LTL) properties. For each property class, we give a deductive proof rule that --- provided a symbolic representation of the game players --- describes a winning strategy for a particular player. Our rules are sound and relatively complete. We show that these rules can be automated by using an off-the-shelf Horn constraint solver that supports existential quantification in clause heads. The practical promise of the rules is demonstrated through several case studies …