Authors
LE Kuil, TMCK Varkevisser, MH Huisman, M Jansen, J Bunt, A Compter, H Ket, SB Schagen, AYN Schouten-van Meeteren, M Partanen
Publication date
2023/12/21
Source
Neuroscience & Biobehavioral Reviews
Pages
105514
Publisher
Pergamon
Description
Background
Cancer survivors frequently experience cognitive impairments. This systematic review assessed animal literature to identify artificial (pharmaceutical) or natural interventions (plant/endogenously-derived) to reduce treatment-related cognitive impairments.
Methods
PubMed, EMBASE, PsycINFO, Web of Science, and Scopus were searched and SYRCLE’s tool was used for risk of bias assessment of the 134 included articles.
Results
High variability was observed and risk of bias analysis showed overall poor quality of reporting. Results generally showed positive effects in the intervention group versus cancer-therapy only group (67% of 156 cognitive measures), with only 15 (7%) measures reporting cognitive impairment despite intervention. Both artificial (61%) and natural (75%) interventions prevented cognitive impairment. Artificial interventions involving GSK3B inhibitors, PLX5622, and NMDA receptor …
Total citations
20241
Scholar articles
LE Kuil, T Varkevisser, MH Huisman, M Jansen, J Bunt… - Neuroscience & Biobehavioral Reviews, 2023