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Ductile fracture generally relates to microscopic voiding and to strain localization in metallic materials. When the void size is reduced to the nanoscale, size effects often lead to a different macroscopic plastic behavior from that established for the same material with larger voids. For example, irradiation of metallic materials can generate a large number of voids at the nanoscale, leading to complex deformation behaviors. The present work advances the understanding of strain localization in nanoporous metallic materials, connecting both the microscopic (nano-) and macroscopic scales. To explore the physical mechanisms at the nanoscale, molecular dynamics (MD) simulations were here carried out, capturing multiple nanovoids explicitly. Then, a homogenized continuum theory based in Gurson’s constitutive framework is proposed, which enables us to explore how localized behavior at the macroscopic scale …