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Evidence suggests a link between physical exercise and many neurological parameters including hippocampal neurochemistry, neuronal activity, expression of neurotrophic growth factor, and spatial learning. The purpose of this study was to determine if access to different frequency and intensity of physical activity and exercise affects spatial maze learning, which is an indication of cognition and adaptation. Thirty six Female Sprague Dawley rats were separated into three groups (n= 12): 1) having no access to physical activity, 2) having access to twice-weekly physical activity in a large box, and 3) having regular access to a running wheel. At age 3 months, performance on a spatial maze was evaluated based upon total time to collect 5 reinforcements (correct responses) and number of working errors (returning to the same place on the maze for reinforcements) and reference errors (going to …