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The standard experimental paradigm in the social, behavioral, and economic sciences is extremely limited. Although recent advances in digital technologies and crowdsourcing services allow individual experiments to be deployed and run faster than in traditional physical labs, a majority of experiments still focus on one-off results that do not generalize easily to real-world contexts or even to other variations of the same experiment. As a result, there exist few universally acknowledged findings, and even those are occasionally overturned by new data. We argue that to achieve replicable, generalizable, scalable and ultimately useful social and behavioral science, a fundamental rethinking of the model of virtual-laboratory style experiments is required. Not only is it possible to design and run experiments that are radically different in scale and scope than was possible in an era of physical labs; this ability allows us to ask fundamentally different types of questions than have been asked historically of lab studies. We posit, however, that taking full advantage of this new and exciting potential will require four major changes to the infrastructure, methodology, and culture of experimental science:(1) significant investments in software design and participant recruitment,(2) innovations in experimental design and analysis of experimental data,(3) adoption of new models of collaboration, and (4) a new understanding of the nature and role of theory in experimental social and behavioral science. We conclude that the path we outline, although ambitious, is well within the power of current technology and has the potential to facilitate a new class of scientific …