Authors
Stefan Blankenberg, Veikko Salomaa, Nataliya Makarova, Francisco Ojeda, Philipp Wild, Karl J Lackner, Torben Jørgensen, Barbara Thorand, Annette Peters, Matthias Nauck, Astrid Petersmann, Erkki Vartiainen, Giovanni Veronesi, Paolo Brambilla, Simona Costanzo, Licia Iacoviello, Gerard Linden, John Yarnell, Christopher C Patterson, Brendan M Everett, Paul M Ridker, Jukka Kontto, Renate B Schnabel, Wolfgang Koenig, Frank Kee, Tanja Zeller, Kari Kuulasmaa
Publication date
2016/8/7
Journal
European heart journal
Volume
37
Issue
30
Pages
2428-2437
Publisher
Oxford University Press
Description
Aims
Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE, to test a potentially clinically relevant cut-off value, and to evaluate the improved eligibility for statin therapy based on elevated troponin I concentrations retrospectively.
Methods and results
Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, we analysed individual level data from 10 prospective population-based studies including 74 738 participants. We investigated the value of adding troponin I levels to conventional risk factors for prediction of cardiovascular disease by calculating measures of discrimination (C-index) and net reclassification improvement (NRI). We further tested …
Scholar articles
S Blankenberg, V Salomaa, N Makarova, F Ojeda… - European heart journal, 2016