Authors
Karin Hek, Ayse Demirkan, Jari Lahti, Antonio Terracciano, Alexander Teumer, Marilyn C Cornelis, Najaf Amin, Erin Bakshis, Jens Baumert, Jingzhong Ding, Yongmei Liu, Kristin Marciante, Osorio Meirelles, Michael A Nalls, Yan V Sun, Nicole Vogelzangs, Lei Yu, Stefania Bandinelli, Emelia J Benjamin, David A Bennett, Dorret Boomsma, Alessandra Cannas, Laura H Coker, Eco De Geus, Philip L De Jager, Ana V Diez-Roux, Shaun Purcell, Frank B Hu, Eric B Rimm, David J Hunter, Majken K Jensen, Gary Curhan, Kenneth Rice, Alan D Penman, Jerome I Rotter, Nona Sotoodehnia, Rebecca Emeny, Johan G Eriksson, Denis A Evans, Luigi Ferrucci, Myriam Fornage, Vilmundur Gudnason, Albert Hofman, Thomas Illig, Sharon Kardia, Margaret Kelly-Hayes, Karestan Koenen, Peter Kraft, Maris Kuningas, Joseph M Massaro, David Melzer, Antonella Mulas, Cornelis L Mulder, Anna Murray, Ben A Oostra, Aarno Palotie, Brenda Penninx, Astrid Petersmann, Luke C Pilling, Bruce Psaty, Rajesh Rawal, Eric M Reiman, Andrea Schulz, Joshua M Shulman, Andrew B Singleton, Albert V Smith, Angelina R Sutin, André G Uitterlinden, Henry Völzke, Elisabeth Widen, Kristine Yaffe, Alan B Zonderman, Francesco Cucca, Tamara Harris, Karl-Heinz Ladwig, David J Llewellyn, Katri Räikkönen, Toshiko Tanaka, Cornelia M Van Duijn, Hans J Grabe, Lenore J Launer, Kathryn L Lunetta, Thomas H Mosley Jr, Anne B Newman, Henning Tiemeier, Joanne Murabito
Publication date
2013/4/1
Journal
Biological psychiatry
Volume
73
Issue
7
Pages
667-678
Publisher
Elsevier
Description
BACKGROUND
Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms.
METHODS
In this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of the independent top hits (p<1×10−5) was performed in five studies assessing depressive symptoms with other instruments. In addition, we performed a combined meta-analysis of all 22 discovery and replication studies.
RESULTS
The discovery sample comprised 34,549 individuals (mean age of 66.5) and no loci reached genome-wide significance (lowest p = 1.05×10−7). Seven independent single nucleotide …
Scholar articles
K Hek, A Demirkan, J Lahti, A Terracciano, A Teumer… - Biological psychiatry, 2013