Authors
Najaf Amin, Elaine Byrne, J Johnson, Georgia Chenevix-Trench, Stefan Walter, IM Nolte, JM Vink, Rajesh Rawal, Massimo Mangino, Alexander Teumer, JC Keers, Germaine Verwoert, Sebastian Baumeister, Reiner Biffar, Astrid Petersmann, N Dahmen, Angela Doering, Aaron Isaacs, Linda Broer, NR Wray, GW Montgomery, Daniel Levy, BM Psaty, Vilmundur Gudnason, Aravinda Chakravarti, Patrick Sulem, DF Gudbjartsson, LA Kiemeney, Unnur Thorsteinsdottir, Kari Stefansson, FJA Van Rooij, YS Aulchenko, Jouke Jan Hottenga, FR Rivadeneira, A Hofman, AG Uitterlinden, CJ Hammond, So Youn Shin, Arfan Ikram, JCM Witteman, ACJW Janssens, Harold Snieder, Henning Tiemeier, BHR Wolfenbuttel, BA Oostra, AC Heath, Eric Wichmann, TD Spector, Hans Jörgen Grabe, DI Boomsma, NG Martin, CM Van Duijn
Publication date
2012/11
Journal
Molecular psychiatry
Volume
17
Issue
11
Pages
1116-1129
Publisher
Nature Publishing Group
Description
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N= 18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis treating different cell lines with caffeine. Genome-wide significant association was observed for two single-nucleotide polymorphisms (SNPs) in the 15q24 region. The two SNPs rs2470893 and rs2472297 (P-values= 1.6× 10− 11 and 2.7× 10− 11), which were also in strong linkage disequilibrium (r 2= 0.7) with each other, lie in the 23-kb long commonly shared 5′ flanking region between CYP1A1 and CYP1A2 genes. CYP1A1 was found to be downregulated in lymphoblastoid cell lines treated with caffeine. CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of …
Total citations
Scholar articles
N Amin, E Byrne, J Johnson, G Chenevix-Trench… - Molecular psychiatry, 2012