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This Report focuses on health governance of vector-borne diseases in Southeast Asia, analysed from the context of threats and opportunities brought about by climate change, urbanisation and globalisation. It first discusses regional health governance in ASEAN and the mechanisms and frameworks that have been established to promote health security, with particular focus on vector-borne diseases. It then provides a background on dengue in Southeast Asian countries, the economic burden of the disease and the regional prevention and control measures that have been implemented so far. The Report also presents a SWOT analysis that assesses the health governance systems of two Southeast Asian countries–Indonesia and Malaysia–with a particular focus on the institutions, networks and the effectiveness of domestic vector prevention and control measures. It assesses the level of integration that regional frameworks and domestic measures have achieved and policy shifts from reactive towards preventive and sustainable long term solutions. Finally, the Report lays out a number of policy recommendations relevant to regional dengue prevention and control.