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In the present study, we have observed the development of an inflammatory reaction in the rat hindpaw, following the injection of specific agonists of PAR₂ (two PAR₂ activating peptides). This inflammation was characterized by oedema and granulocyte infiltration.

Two selective PAR₂ activating peptides, SLGRL‐NH₂ and trans‐cinnamoyl‐LIGRLO‐NH₂ induced significant oedema in the rat hindpaw from 1–6 h following subplantar injection. Six hours after the PAR₂‐activating peptide injection, the paw tissues showed a complete disruption of tissue architecture along with an inflammatory cell infiltrate.

In the inflamed paw, PAR₂‐immunoreactivity was expressed on endothelial cells as well as on the infiltrating inflammatory cells.

The oedema induced by the injection of the two PAR₂ activating peptides was slightly reduced in rats pre‐treated with compound 48/80, but was not modified by pre‐treatment of rats …