Authors
Kyung-Seon Kim, Ghi-Su Kim, Joo-Yeon Hwang, Hye-Ja Lee, Mi-Hyun Park, Kwang-joong Kim, Jongsun Jung, Hyo-Soung Cha, Hyoung Doo Shin, Jong-Ho Kang, Eui Kyun Park, Tae-Ho Kim, Jung-Min Hong, Jung-Min Koh, Bermseok Oh, Kuchan Kimm, Shin-Yoon Kim, Jong-Young Lee
Publication date
2007/12
Journal
BMC Medical Genetics
Volume
8
Pages
1-13
Publisher
BioMed Central
Description
Background
Osteoporosis is defined as the loss of bone mineral density that leads to bone fragility with aging. Population-based case-control studies have identified polymorphisms in many candidate genes that have been associated with bone mass maintenance or osteoporotic fracture. To investigate single nucleotide polymorphisms (SNPs) that are associated with osteoporosis, we examined the genetic variation among Koreans by analyzing 81 genes according to their function in bone formation and resorption during bone remodeling.
Methods
We resequenced all the exons, splice junctions and promoter regions of candidate osteoporosis genes using 24 unrelated Korean individuals. Using the common SNPs from our study and the HapMap database, a statistical analysis of deviation in heterozygosity depicted.
Results …
Scholar articles
KS Kim, GS Kim, JY Hwang, HJ Lee, MH Park, K Kim… - BMC Medical Genetics, 2007