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In a closed-loop supply chain (CLSC) network, there are both forward and reverse supply chains. In this research, a tire remanufacturing CLSC network is designed and optimized based on tire recovery options. The objective of the optimization model is to maximize the total profit. The optimization model includes multiple products, suppliers, plants, retailers, demand markets, and drop-off depots. The application of the model is discussed based on a realistic network in Toronto, Canada using map. In addition, a new decision tree-based methodology is provided to calculate the net present value of the problem in multiple periods under different sources of uncertainty such as demand and returns. Furthermore, the discount cash flow is considered in the methodology as a novel innovative approach. This methodology can be applied in comparing the profitability of different design options for CLSCs.