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A closed-loop supply chain (CLSC) network consists of both forward and reverse supply chains. In this paper, a CLSC network is investigated which includes multiple plants, collection centres, demand markets, and products. To this aim, a mixed-integer linear programming model is proposed that minimizes the total cost. Besides, two test problems are examined. The model is extended to consider environmental factors by weighed sums and ε-constraint methods. In addition, we investigate the impact of demand and return uncertainties on the network configuration by stochastic programming (scenario-based). Computational results show that the model can handle demand and return uncertainties, simultaneously.