Authors
Lokien X van Nunen, Frederik M Zimmermann, Pim AL Tonino, Emanuele Barbato, Andreas Baumbach, Thomas Engstrøm, Volker Klauss, Philip A MacCarthy, Ganesh Manoharan, Keith G Oldroyd, Peter N Ver Lee, Marcel Van't Veer, William F Fearon, Bernard De Bruyne, Nico HJ Pijls
Publication date
2015/11/7
Journal
The Lancet
Volume
386
Issue
10006
Pages
1853-1860
Publisher
Elsevier
Description
Background
In the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) study, fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) improved outcome compared with angiography-guided PCI for up to 2 years of follow-up. The aim in this study was to investigate whether the favourable clinical outcome with the FFR-guided PCI in the FAME study persisted over a 5-year follow-up.
Methods
The FAME study was a multicentre trial done in Belgium, Denmark, Germany, the Netherlands, Sweden, the UK, and the USA. Patients (aged ≥18 years) with multivessel coronary artery disease were randomly assigned to undergo angiography-guided PCI or FFR-guided PCI. Before randomisation, stenoses requiring PCI were identified on the angiogram. Patients allocated to angiography-guided PCI had revascularisation of all identified stenoses. Patients allocated to FFR …
Scholar articles
LX van Nunen, FM Zimmermann, PAL Tonino… - The Lancet, 2015