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The current paper focuses on a sector of the historic centre of Muccia, in the district of Macerata (Italy), affected by the seismic sequence that involved Central Italy in 2016. The main goal is comparison, in terms of fragility curves, among two vulnerability assessment methodologies (empirical and mechanical). The study area has been structurally and typologically identified according to the Building Typology Matrix (BTM). Physical vulnerability analysis of the urban-sector was performed through application of an index-based method, specifically for masonry building aggregates. An isolated masonry building, damaged after the seismic sequences, has been selected as a case study. For the assessed building, empirical fragility curves are presented according to Guagenti & Petrini’s correlation law. Furthermore, a numerical model has been set up by using the macro-element approach, which has allowed to perform …