Authors
Usha Menon, Aleksandra Gentry-Maharaj, Rachel Hallett, Andy Ryan, Matthew Burnell, Aarti Sharma, Sara Lewis, Susan Davies, Susan Philpott, Alberto Lopes, Keith Godfrey, David Oram, Jonathan Herod, Karin Williamson, Mourad W Seif, Ian Scott, Tim Mould, Robert Woolas, John Murdoch, Stephen Dobbs, Nazar N Amso, Simon Leeson, Derek Cruickshank, Alistair Mcguire, Stuart Campbell, Lesley Fallowfield, Naveena Singh, Anne Dawnay, Steven J Skates, Mahesh Parmar, Ian Jacobs
Publication date
2009/4/1
Journal
The lancet oncology
Volume
10
Issue
4
Pages
327-340
Publisher
Elsevier
Description
Background
Ovarian cancer has a high case–fatality ratio, with most women not diagnosed until the disease is in its advanced stages. The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is a randomised controlled trial designed to assess the effect of screening on mortality. This report summarises the outcome of the prevalence (initial) screen in UKCTOCS.
Methods
Between 2001 and 2005, a total of 202 638 post-menopausal women aged 50–74 years were randomly assigned to no treatment (control; n=101 359); annual CA125 screening (interpreted using a risk of ovarian cancer algorithm) with transvaginal ultrasound scan as a second-line test (multimodal screening [MMS]; n=50 640); or annual screening with transvaginal ultrasound (USS; n=50 639) alone in a 2:1:1 ratio using a computer-generated random number algorithm. All women provided a blood sample at recruitment …
Total citations
Scholar articles
U Menon, A Gentry-Maharaj, R Hallett, A Ryan… - The lancet oncology, 2009