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The continued success of Deep Neural Networks (DNNs) in classification tasks has sparked a trend of accelerating their execution with specialized hardware. While published designs easily give an order of magnitude improvement over general-purpose hardware, few look beyond an initial implementation. This paper presents Minerva, a highly automated co-design approach across the algorithm, architecture, and circuit levels to optimize DNN hardware accelerators. Compared to an established fixed-point accelerator baseline, we show that fine-grained, heterogeneous datatype optimization reduces power by 1.5×; aggressive, inline predication and pruning of small activity values further reduces power by 2.0×; and active hardware fault detection coupled with domain-aware error mitigation eliminates an additional 2.7× through lowering SRAM voltages. Across five datasets, these optimizations provide a collective …