Authors
C Spampinato, E Aguglia, C Concerto, M Pennisi, G Lanza, R Bella, M Cantone, G Pennisi, I Kavasidis, D Giordano
Publication date
2013/4/3
Journal
IEEE transactions on neural systems and rehabilitation engineering
Volume
21
Issue
3
Pages
391-403
Publisher
IEEE
Description
Major depression is one of the leading causes of disabling condition worldwide and its treatment is often challenging and unsatisfactory, since many patients become refractory to pharmacological therapies. Transcranial magnetic stimulation (TMS) is a noninvasive neurophysiological investigation mainly used to study the integrity of the primary motor cortex excitability and of the cortico-spinal tract. The development of paired-pulse and repetitive TMS (rTMS) paradigms has allowed investigators to explore the pathophysiology of depressive disorders and other neuropsychiatric diseases linked to brain excitability dysfunctions. Repetitive transcranial magnetic stimulation has also therapeutic and rehabilitative capabilities since it is able to induce changes in the excitability of inhibitory and excitatory neuronal networks that may persist in time. However, the therapeutic effects of rTMS on major depression have been …
Scholar articles
C Spampinato, E Aguglia, C Concerto, M Pennisi… - IEEE transactions on neural systems and rehabilitation …, 2013