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This paper presents an automatic system for bone age evaluation according to the clinical method of Tanner and Whitehouse (TW2), based on the integration between two systems: The first processes the finger's bones [epiphysis/metaphysis region of interest (EMROI)], whereas the second one processes the wrist bones [carpal region of interest (CROI)]. The system ensures an accurate bone age assessment for age ranges of 0-10 years for males and 0-7 years for females. For both approaches, novel segmentation techniques are proposed. In detail, for CROI analysis, bone extraction is carried out by integrating anatomical knowledge of the hand and trigonometric concepts, whereas a TW2-stage assignment is achieved by combining the gradient vector flow Snakes and the derivative difference of Gaussian filter. One of the main difficulties for bone age assessment based on carpal bones is that trapezium and …