Authors
Philippe Guardiola, Volker Runde, Andrea Bacigalupo, Tapani Ruutu, Franco Locatelli, Marc A Boogaerts, Antonio Pagliuca, Jan J Cornelissen, Harry C Schouten, Enric Carreras, Jürgen Finke, Anja van Biezen, Ronald Brand, Dietger Niederwieser, Eliane Gluckman, Theo M de Witte
Publication date
2002/6/15
Journal
Blood, The Journal of the American Society of Hematology
Volume
99
Issue
12
Pages
4370-4378
Publisher
American Society of Hematology
Description
In this multicenter retrospective study, the outcomes of 234 patients with myelodysplastic syndrome (MDS) who underwent transplantation between 1995 and 1999 from HLA-identical siblings were analyzed according to the hematopoietic stem cell source used, that is, bone marrow (BM, n = 132) or granulocyte colony-stimulating factor–mobilized peripheral blood progenitor cells (PBPCs, n = 102). There were 69 cases of refractory anemia (RA), 86 RA with excess blasts (RAEB), 75 RAEB in transformation (RAEB-t), and 4 unclassified MDS at diagnosis. The International Prognostic Scoring System was intermediate-2 or high in 104 of the 158 available scores. Multivariate analyses focused on transplantation-related mortality (TRM), 2-year treatment failure incidence, and survival. Use of PBPCs reduced the median duration of neutropenia and thrombocytopenia by 4 and 12 days, respectively. The incidence of …
Total citations
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