Authors
Selim Corbacioglu, Enric Carreras, Marc Ansari, Adriana Balduzzi, Simone Cesaro, Jean Hugues Dalle, F Dignan, Brenda Gibson, Tayfun Guengoer, Bernd Gruhn, Arjan Lankester, Franco Locatelli, Antonio Pagliuca, Christina Peters, Paul G Richardson, Ansgar S Schulz, Petr Sedlacek, Jerry Stein, Karl-Walter Sykora, Jacek Toporski, Eugenia Trigoso, Kim Vetteranta, Jacek Wachowiak, Elisabeth Wallhult, Robert Wynn, Isaac Yaniv, Akif Yesilipek, Mohamad Mohty, Peter Bader
Publication date
2018/2
Journal
Bone marrow transplantation
Volume
53
Issue
2
Pages
138-145
Publisher
Nature Publishing Group
Description
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within weeks; however, severe SOS/VOD results in multi-organ dysfunction/failure with a mortality rate> 80%. A timely diagnosis of SOS/VOD is of critical importance, given the availability of therapeutic options with favorable tolerability. Current diagnostic criteria are used for adults and children. However, over the last decade it has become clear that SOS/VOD is significantly different between the age groups in terms of incidence, genetic predisposition, clinical presentation, prevention, treatment and outcome. Improved …
Scholar articles
S Corbacioglu, E Carreras, M Ansari, A Balduzzi… - Bone marrow transplantation, 2018