Authors
Xiangrui Meng, Olga Giannakopoulou, Georgina Navoly, Daniel Levey, Brittany Mitchell, Adrielle M Oliveira, Nicholas G Martin, Giovanni Salum, Murray B Stein, Joel Gelernter, Sintia Belangero, Vanessa Ota, Andrew McIntosh, Cathryn Lewis, Karoline Kuchenbaecker
Publication date
2023/10/1
Journal
European Neuropsychopharmacology
Volume
75
Pages
S65-S66
Publisher
Elsevier
Description
Background
Genome-wide association studies (GWAS) in individuals of European ancestry have identified >200 loci for major depression (MD). There has been a slow increase in ancestral diversity of participants. Most previous studies assigned subjects to ancestry groups based on genetic similarity to reference samples. Individuals who could not be assigned, especially those with mixed ancestry, were routinely excluded, leading to ethical concerns and missed scientific opportunities. To address this, we conducted a large GWAS meta-analysis of MD in samples from mixed-ancestry populations using an ancestry-aware mixed model.
Methods
This project included 12 cohorts which had recruited individuals with diverse ethnicity, including the UK Biobank (UKB), WHI, HCHS/SOL, GERA, IHS, Army-STARRS, eMERGE, QIMRB, MESA, BHRCS, HELIUS and the MVP. Results reported here were based on a subset of …
Scholar articles
X Meng, O Giannakopoulou, G Navoly, D Levey… - European Neuropsychopharmacology, 2023