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More information is needed on how quality of life was impacted by the recent pandemic, as little comparative data to pre-pandemic levels are available. This study examined how the quality of life of college students was affected during the COVID-19 crisis and lockdown in Cyprus, with a two-wave measurement design, which included a pre-pandemic baseline. The effect of emotion regulation styles on quality of life change was examined, using measures associated with 2nd and 3rd wave Cognitive Behavioral Therapy approaches, in an effort to identify processes associated with vulnerability and malleable risk factors that can be improved through intervention. Significant decreases in total, physical and psychological quality of life were observed relative to pre-pandemic levels. Significant predictors of decline in quality of life relative to pre-pandemic baseline were difficulty describing feelings and difficulty accessing …