Authors
Bianca Rocca, Francesca Santilli, Dario Pitocco, Luciana Mucci, Giovanna Petrucci, Ester Vitacolonna, Stefano Lattanzio, Domenico Mattoscio, Francesco Zaccardi, Rossella Liani, Natale Vazzana, A Del Ponte, Elisabetta Ferrante, Francesca Martini, Carmine Cardillo, Roberta Morosetti, Massimiliano Mirabella, Giovanni Ghirlanda, Giovanni Davi, Carlo Patrono
Publication date
2012/7/1
Journal
Journal of Thrombosis and Haemostasis
Volume
10
Issue
7
Pages
1220-1230
Publisher
Elsevier
Description
See also Lordkipanidze M, Harrison P. Aspirin twice a day keeps new COX‐1 at bay. This issue, pp 1217–9.
Summary Background
Interindividual variability in response to aspirin has been popularized as ‘resistance’. We hypothesized that faster recovery of platelet cyclooxygenase‐1 activity may explain incomplete thromboxane (TX) inhibition during the 24‐h dosing interval.
Objective
To characterize the kinetics and determinants of platelet cyclooxygenase‐1 recovery in aspirin‐treated diabetic and non‐diabetic patients.
Patients/Methods
One hundred type 2 diabetic and 73 non‐diabetic patients on chronic aspirin 100 mg daily were studied. Serum TXB2 was measured every 3 h, between 12 and 24 h after a witnessed aspirin intake, to characterize the kinetics of platelet cyclooxygenase‐1 recovery. Patients with the fastest TXB2 recovery were randomized to aspirin 100 mg once daily, 200 mg once daily or 100 …
Total citations
Scholar articles
B Rocca, F Santilli, D Pitocco, L Mucci, G Petrucci… - Journal of Thrombosis and Haemostasis, 2012