Authors
Yong Xu, Weihua Yue, Yin Yao Shugart, Sheng Li, Lei Cai, Qiang Li, Zaohuo Cheng, Guoqiang Wang, Zhenhe Zhou, Chunhui Jin, Jianmin Yuan, Lin Tian, Jun Wang, Kai Zhang, Kerang Zhang, Sha Liu, Yuqing Song, Fuquan Zhang
Publication date
2016/7/1
Journal
Schizophrenia bulletin
Volume
42
Issue
4
Pages
1037-1045
Publisher
Oxford University Press
Description
Background
Transcriptional factors (TFs) and microRNAs (miRNAs) have been recognized as 2 classes of principal gene regulators that may be responsible for genome coexpression changes observed in schizophrenia (SZ).
Methods
This study aims to (1) identify differentially coexpressed genes (DCGs) in 3 mRNA expression microarray datasets; (2) explore potential interactions among the DCGs, and differentially expressed miRNAs identified in our dataset composed of early-onset SZ patients and healthy controls; (3) validate expression levels of some key transcripts; and (4) explore the druggability of DCGs using the curated database.
Results
We detected a differential coexpression network associated with SZ and found that 9 out of the 12 regulators were replicated in either of the 2 other datasets. Leveraging the differentially expressed …
Scholar articles
Y Xu, W Yue, Y Yao Shugart, S Li, L Cai, Q Li, Z Cheng… - Schizophrenia bulletin, 2016