Authors
Antonella Olivieri, Emanuela Medda, Simona De Angelis, Herbert Valensise, Mario De Felice, Cristina Fazzini, Isabella Cascino, Viviana Cordeddu, Mariella Sorcini, Maria Antonietta Stazi
Publication date
2007/8/1
Journal
The Journal of Clinical Endocrinology & Metabolism
Volume
92
Issue
8
Pages
3141-3147
Publisher
Oxford University Press
Description
Context: In Italy, the surveillance of congenital hypothyroidism (CH) is performed by the Italian National Registry of Infants with CH (INRICH). Up to now, about 3600 infants with CH are recorded in the INRICH, and a high number of twins are included.
Objective: Our objective was to estimate the risk of CH in multiple and single deliveries and to compare neonatal features of CH twins with twins from the general population.
Design: The Italian population of CH infants recorded in the INRICH from 1989–2000 was investigated.
Results: A more than 3-fold higher frequency of twins was found in the CH population than in the general population, and for the first time, it was possible to estimate the CH incidence in multiple (10.1 in 10,000) and single deliveries (3.2 in 10,000 live births). Significantly higher frequencies of in situ gland as well as lower TSH mean level at screening …
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Scholar articles
A Olivieri, E Medda, S De Angelis, H Valensise… - The Journal of Clinical Endocrinology & Metabolism, 2007