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The present study was carried out to determine the antioxidant and iron chelating property of 70% methanolic extract of 'katha' (heartwood extract of Acacia catechu). The extract was found to be an antioxidant with a TEAC value of 0.72 ± 0.02. The extract has shown its scavenging activity for different radical and 17.8 ± 0.63 ?g/ml, 39.55 ± 1.36 ?g/ml, 55.31 ± 7.12 ?g/ml, 746.85 ± 30.46 ?g/ml, 44.2 ± 4.48 mg/ml, 57.5 ± 4.23 ?g/ml, 155.48 ± 3.78 ?g/ml were determined as IC50 value for DPPH, superoxide, nitric oxide, peroxynitrite, hydrogen peroxide, singlet oxygen and hypochlorous acid radicals, respectively. The plant was found to inhibit lipid peroxidation with an IC50 of 12.35 ± 0.43 ?g/ml. The extract also has the ability to chelate iron with an IC50 of 810.8 ± 20.74 ?g/ml as well as DNA protective property with [P]50 of 60.44 ± 5.73 ?g/ml. It was also observed that the plant extract (100 mg) has 97.13 ± 0.006 mg/ml …