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The Indus, Mekong, and Ganges River deltas, which have created one of the world’s largest delta and submarine fan system, currently contribute a major fraction of freshwater to East and South Asia. All these deltas are those regions in the world that face major challenges in their water sector due to population growth, urbanization, industrialization, sea-level rise, and salinity intrusion into inland and water bodies, all aggravated by climate change. Among them, salinity intrusion is currently one of the key issues that directly and indirectly cause water insecurity in East and South Asia, which ultimately hamper livelihood, agricultural production, and social interference. Hence, this chapter gives a comprehensive description on the nature and extent of the salinity problem, its adverse effects on livelihood and water sector, and then the focus goes to current and future sustainable water resource management within the …