Authors
June L Round, Sarkis K Mazmanian
Publication date
2010/7/6
Journal
Proceedings of the National Academy of Sciences
Volume
107
Issue
27
Pages
12204-12209
Publisher
National Academy of Sciences
Description
To maintain intestinal health, the immune system must faithfully respond to antigens from pathogenic microbes while limiting reactions to self-molecules. The gastrointestinal tract represents a unique challenge to the immune system, as it is permanently colonized by a diverse amalgam of bacterial phylotypes producing multitudes of foreign microbial products. Evidence from human and animal studies indicates that inflammatory bowel disease results from uncontrolled inflammation to the intestinal microbiota. However, molecular mechanisms that actively promote mucosal tolerance to the microbiota remain unknown. We report herein that a prominent human commensal, Bacteroides fragilis, directs the development of Foxp3+ regulatory T cells (Tregs) with a unique “inducible” genetic signature. Monocolonization of germ-free animals with B. fragilis increases the suppressive capacity of Tregs and induces anti …
Total citations
Scholar articles
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
JL Round, SK Mazmanian - Proceedings of the National Academy of Sciences, 2010