Authors
Nordin MJ Hanssen, Kristiaan Wouters, Maya S Huijberts, Marion J Gijbels, Judith C Sluimer, Jean LJM Scheijen, Sylvia Heeneman, Erik AL Biessen, Mat JAP Daemen, Michael Brownlee, Dominique P De Kleijn, Coen DA Stehouwer, Gerard Pasterkamp, Casper G Schalkwijk
Publication date
2014/5/1
Journal
European heart journal
Volume
35
Issue
17
Pages
1137-1146
Publisher
Oxford University Press
Description
Aims
Rupture-prone atherosclerotic plaques are characterized by inflammation and a large necrotic core. Inflammation is linked to high metabolic activity. Advanced glycation endproducts (AGEs) and their major precursor methylglyoxal are formed during high metabolic activity and can have detrimental effects on cellular function and may induce cell death. Therefore, we investigated whether plaque AGEs are increased in human carotid rupture-prone plaques and are associated with plaque inflammation and necrotic core formation.
Methods and results
The protein-bound major methylglyoxal-derived AGE 5-hydro-5-methylimidazolone (MG-H1) and Nɛ-(carboxymethyl)lysine (CML) were measured in human carotid endarterectomy specimens (n = 75) with tandem mass spectrometry. MG-H1 and CML levels were associated with rupture-prone plaques, increased protein levels …
Scholar articles
NMJ Hanssen, K Wouters, MS Huijberts, MJ Gijbels… - European heart journal, 2014