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We present a set of novel algorithms which we call sequenceMiner that detect and characterize anomalies in large sets of high-dimensional symbol sequences that arise from recordings of switch sensors in the cockpits of commercial airliners. While the algorithms that we present are general and domain-independent, we focus on a specific problem that is critical to determining the system-wide health of a fleet of aircraft. The approach taken uses unsupervised clustering of sequences using the normalized length of the longest common subsequence as a similarity measure, followed by detailed outlier analysis to detect anomalies. In this method, an outlier sequence is defined as a sequence that is far away from the cluster center. We present new algorithms for outlier analysis that provide comprehensible indicators as to why a particular sequence is deemed to be an outlier. The algorithms provide a coherent …