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Regardless of how the concept of a ‘place’ is geographically defined, be it cities, regions, nations or otherwise, the impact of new technologies will influence much of our business, social, and economic landscapes. Evidently, there is an increasing pressure on ‘places’ to embrace new opportunities for strategic development and confront complacency that retards change. The solution may very well be in creating and sustaining entrepreneurial ecosystems where entrepreneurial action thrives and innovation drives the new economy. However, defining the entrepreneurial ecosystem remains difficult and the methods used to analyse them are inconsistent. This chapter deals with the theoretical foundations of an entrepreneurial ecosystem when it is specifically considered as a place-based change management instrument. As we introduce the variety of submitted works to this volume it becomes apparent that …