Authors
Mitchell SV Elkind, Jorge M Luna, Leslie A McClure, Yu Zhang, Christopher S Coffey, Ana Roldan, Oscar H Del Brutto, Edwin Javier Pretell, L Creed Pettigrew, Brett C Meyer, Jorge Tapia, Carole White, Oscar R Benavente, LIMITS Investigators, Clinical Sites in Order of Number of Participants (n) Enrolled, United States, 31 sites (n= 639), University of Kentucky, Lexington, KY, Creed Pettigrew, Anand Vaishnav, Peter Sawaya, Anna Fowler, Nedda Hughes, Johnya Rice, Kathy Vanderpool, University of California San Diego, San Diego, CA, Brett Meyer, Christy Jackson, Paul Gamble, Nancy Kelly, Janet Warner, Jo Bell, Rochester Stroke Center, Rochester, MN, Irene Meissner, John Graves, Deb Herzig, Jody Covalt, St Louis University, St Louis, MO, Salvador Cruz-Flores, H Douglas Walden, Eve Holzemer, University of Arizona, Tucson, AZ, Bruce Coull, Lien Howard, Mina Malekniazi, Melissa VanSkiver, Denise Bruck, Stacey Redman, Metrohealth Medical Center, Cleveland, OH, Joseph Hanna, Thomas Zipp, Scott Bailey, Dana Cook, Alice Liskay, Dana Simcox, Joan Kappler, Mayo Clinic Scottsdale, Scottsdale, AZ, Bart Demaerschalk, Michael Hogan, Daniel Wochos, Judith Wieser, Barbara Cleary, Lori Wood, Henry Ford Hospital, Detroit, MI, Angelo Katramados, Brian Silver, Jerry Yee, Krisy Aiello, Kathleen Wilson, Sharon McCarthy, Boston University, Boston, MA, Carlos Kase, Irene Gavras, Helena Lau, Matt Ogrodnik, Nancy Allen, Berman Center for Clinical Research, Minneapolis, MN, David Anderson, Richard Grimm, Donna Brauer, University of South Alabama, Mobile, AL, Dean Naritoku, Richard Zweifler, Michael Culpepper, Mel Parnell, Robin Yunker, Kelly Boots, Renay Drinkard, Rachel Backlin, Columbia University Medical Center, New York, NY, Mitch Elkind, Russell John Crew, Jai Radhakrishan, Tania E Corporan, Julisa Diaz, Rebeca Aragon, University of Texas Health Science Center at San Antonio, San Antonio, TX, Oscar Benavente, Robert Hart, Pablo Pergola, Santiago Palacio, Irma Castro, Arlene Farias, Ana Roldan, Cooper Health System Department of Medicine, Camden, NJ, Tom Mirsen, Susan McAllister, Arnaud Bastien, Patricia Niblack, University Hospitals Case Medical Center, Cleveland, OH, Sophia Sundararajan, Mahboob Rahman, Tom Horvath, David Korosec, Chris Murphy, Oregon Health and Science University, Portland, OR, Helmi Lutsep, Don Girard, Kali Seisler, Megan Cingel, Megan Ross, Rachel Stone, Darren Larsen, Ann Doherty, Medical College of Wisconsin, Milwaukee, WI, Diane Book, Sunu Eapen, Clarence Grimm, Barbara Blaney, Stephanie Rozman, Linda Gaertner, Erin Bradenburg, Laura Loomis, Jolene Monarch-Cotton, Jean Ravavelli-Meyer, Anna Golembieski, University of Miami, Miller School, Miami, FL, José Romano, Gustavo Ortiz, Maria del Carmen Lichtenberger, University of Texas Southwestern, Dallas, TX, Mark Johnson, Yinghui Liu, Robert Goldsteen, April Blair, Gregg Wright, Naomie Gathua, Ruan Neurology Clinic and Research Center, Des Moines, IA, Michael Jacoby, David Jones, Jeffrey DeFrancisco
Publication date
2014/3
Journal
Stroke
Volume
45
Issue
3
Pages
707-716
Publisher
Lippincott Williams & Wilkins
Description
Background and Purpose
Inflammatory biomarkers predict incident and recurrent cardiac events, but their relationship to stroke prognosis is uncertain. We hypothesized that high-sensitivity C-reactive protein (hsCRP) predicts recurrent ischemic stroke after recent lacunar stroke.
Methods
Levels of Inflammatory Markers in the Treatment of Stroke (LIMITS) was an international, multicenter, prospective ancillary biomarker study nested within Secondary Prevention of Small Subcortical Strokes (SPS3), a phase III trial in patients with recent lacunar stroke. Patients were assigned in factorial design to aspirin versus aspirin plus clopidogrel, and higher versus lower blood pressure targets. Patients had blood samples collected at enrollment and hsCRP measured using nephelometry at a central laboratory. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for …
Total citations
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