Authors
Adam Abeshouse, Jaeil Ahn, Rehan Akbani, Adrian Ally, Samirkumar Amin, Christopher D Andry, Matti Annala, Armen Aprikian, Joshua Armenia, Arshi Arora, J Todd Auman, Miruna Balasundaram, Saianand Balu, Christopher E Barbieri, Thomas Bauer, Christopher C Benz, Alain Bergeron, Rameen Beroukhim, Mario Berrios, Adrian Bivol, Tom Bodenheimer, Lori Boice, Moiz S Bootwalla, Rodolfo Borges Dos Reis, Paul C Boutros, Jay Bowen, Reanne Bowlby, Jeffrey Boyd, Robert K Bradley, Anne Breggia, Fadi Brimo, Christopher A Bristow, Denise Brooks, Bradley M Broom, Alan H Bryce, Glenn Bubley, Eric Burks, Yaron SN Butterfield, Michael Button, David Canes, Carlos G Carlotti, Rebecca Carlsen, Michel Carmel, Peter R Carroll, Scott L Carter, Richard Cartun, Brett S Carver, June M Chan, Matthew T Chang, Yu Chen, Andrew D Cherniack, Simone Chevalier, Lynda Chin, Juok Cho, Andy Chu, Eric Chuah, Sudha Chudamani, Kristian Cibulskis, Giovanni Ciriello, Amanda Clarke, Matthew R Cooperberg, Niall M Corcoran, Anthony J Costello, Janet Cowan, Daniel Crain, Erin Curley, Kerstin David, John A Demchok, Francesca Demichelis, Noreen Dhalla, Rajiv Dhir, Alexandre Doueik, Bettina Drake, Heidi Dvinge, Natalya Dyakova, Ina Felau, Martin L Ferguson, Scott Frazer, Stephen Freedland, Yao Fu, Stacey B Gabriel, Jianjiong Gao, Johanna Gardner, Julie M Gastier-Foster, Nils Gehlenborg, Mark Gerken, Mark B Gerstein, Gad Getz, Andrew K Godwin, Anuradha Gopalan, Markus Graefen, Kiley Graim, Thomas Gribbin, Ranabir Guin, Manaswi Gupta, Angela Hadjipanayis, Syed Haider, Lucie Hamel, D Neil Hayes, David I Heiman, Julian Hess, Katherine A Hoadley, Andrea H Holbrook, Robert A Holt, Antonia Holway, Christopher M Hovens, Alan P Hoyle, Mei Huang, Carolyn M Hutter, Michael Ittmann, Lisa Iype, Stuart R Jefferys, Corbin D Jones, Steven JM Jones, Hartmut Juhl, Andre Kahles, Christopher J Kane, Katayoon Kasaian, Michael Kerger, Ekta Khurana, Jaegil Kim, Robert J Klein, Raju Kucherlapati, Louis Lacombe, Marc Ladanyi, Phillip H Lai, Peter W Laird, Eric S Lander, Mathieu Latour, Michael S Lawrence, Kevin Lau, Tucker LeBien, Darlene Lee, Semin Lee, Kjong-Van Lehmann, Kristen M Leraas, Ignaty Leshchiner, Robert Leung, John A Libertino, Tara M Lichtenberg, Pei Lin, W Marston Linehan, Shiyun Ling, Scott M Lippman, Jia Liu, Wenbin Liu, Lucas Lochovsky, Massimo Loda, Christopher Logothetis, Laxmi Lolla
Publication date
2015/11/5
Journal
Cell
Volume
163
Issue
4
Pages
1011-1025
Publisher
Elsevier
Description
There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in …
Scholar articles
A Abeshouse, J Ahn, R Akbani, A Ally, S Amin… - Cell, 2015