Authors
Unnur Styrkarsdottir, Bjarni V Halldorsson, Solveig Gretarsdottir, Daniel F Gudbjartsson, G Bragi Walters, Thorvaldur Ingvarsson, Thorbjorg Jonsdottir, Jona Saemundsdottir, Jacqueline R Center, Tuan V Nguyen, Yu Bagger, Jeffrey R Gulcher, John A Eisman, Claus Christiansen, Gunnar Sigurdsson, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson
Publication date
2008/5/29
Journal
New England Journal of Medicine
Volume
358
Issue
22
Pages
2355-2365
Publisher
Massachusetts Medical Society
Description
Background
Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture.
Methods
We performed a quantitative trait analysis of data from 5861 Icelandic subjects (the discovery set), testing for an association between 301,019 single-nucleotide polymorphisms (SNPs) and bone mineral density of the hip and lumbar spine. We then tested for an association between 74 SNPs (most of which were implicated in the discovery set) at 32 loci in replication sets of Icelandic, Danish, and Australian subjects (4165, 2269, and 1491 subjects, respectively).
Results
Sequence variants in five genomic regions were significantly associated with bone mineral density in the discovery set and were confirmed in the replication sets (combined P values, 1.2×10−7 to 2.0×10−21). Three …
Total citations
Scholar articles
U Styrkarsdottir, BV Halldorsson, S Gretarsdottir… - New England Journal of Medicine, 2008