Authors
Anthony G Johnson, Tuan V Nguyen, Richard O Day
Publication date
1994/8/15
Source
Annals of internal medicine
Volume
121
Issue
4
Pages
289-300
Publisher
American College of Physicians
Description
Purpose
A meta-analysis of randomized trials studying the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on blood pressure.
Data Sources and Study Selection
Eight databases were searched, yielding 38 randomized, placebo-controlled trials and 12 randomized but not placebo-controlled trials (comparing two or more NSAIDs).
Data Extraction
Pooled mean treatment effects were computed in each trial for blood pressure, weight, creatinine clearance, plasma renin activity, and daily urinary excretion of sodium and prostaglandins. Meta-analyses of these variables were done for all randomized, controlled trials; for all randomized, uncontrolled trials; and for several subgroups.
Data Synthesis
When pooled, NSAIDs elevated supine mean blood pressure by 5.0 mm Hg (95% CI, 1.2 to 8.7 mm Hg) but …
Total citations
Scholar articles
AG Johnson, TV Nguyen, RO Day - Annals of internal medicine, 1994