Authors
Alison J Wimms, Julia L Kelly, Christopher D Turnbull, Alison McMillan, Sonya E Craig, John F O'Reilly, Annabel H Nickol, Emma L Hedley, Meredith D Decker, Leslee A Willes, Peter MA Calverley, Adam V Benjafield, John R Stradling, Mary J Morrell, Sophie D West, Anita K Simonds, Shirmila Withana, Justin CT Pepperell, Neil R Ward, Brian D Kent, Timothy Quinnell, Mohammad Paracha, William Anderson
Publication date
2020/4/1
Journal
The Lancet Respiratory Medicine
Volume
8
Issue
4
Pages
349-358
Publisher
Elsevier
Description
Background
The evidence base for the treatment of mild obstructive sleep apnoea is limited and definitions of disease severity vary. The MERGE trial investigated the clinical effectiveness of continuous positive airway pressure in patients with mild obstructive sleep apnoea.
Methods
MERGE, a multicentre, parallel, randomised controlled trial enrolled patients (≥18 years to ≤80 years) with mild obstructive sleep apnoea (apnoea-hypopnoea index [AHI] ≥5 to ≤15 events per h using either AASM 2007 or AASM 2012 scoring criteria) from 11 UK sleep centres. Participants were assigned (1:1) to either 3 months of continuous positive airway pressure plus standard care (sleep counselling), or standard care alone, by computer-generated randomisation; neither participants nor researchers were blinded. The primary outcome was a change in the score on the Short Form-36 questionnaire vitality scale in the intention-to …
Scholar articles
AJ Wimms, JL Kelly, CD Turnbull, A McMillan, SE Craig… - The Lancet Respiratory Medicine, 2020