Uploaded 2021/9/6
Authors
Sau May Wong, Jacobus FA Jansen, C Eleana Zhang, Erik I Hoff, Julie Staals, Robert J van Oostenbrugge, Walter H Backes
Publication date
2019/4/9
Journal
Neurology
Volume
92
Issue
15
Pages
e1669-e1677
Publisher
Lippincott Williams & Wilkins
Description
Objective
To investigate the link between blood-brain-barrier (BBB) permeability and cerebral blood flow (CBF) and the relation with white matter hyperintensities (WMH) in cerebral small vessel disease (cSVD).
Methods
Twenty-seven patients with cSVD received dynamic susceptibility contrast and dynamic contrast-enhanced MRI to determine CBF and BBB permeability (expressed as leakage rate and volume), respectively. Structural MRI were segmented into normal-appearing white matter (NAWM) and WMH, for which a perilesional zone was defined. In these regions, we investigated the BBB permeability, CBF, and their relation using Pearson correlation r.
Results
We found a decrease in CBF of 2.2 mL/min/100 g (p < 0.01) and an increase in leakage volume of 0.7% (p < 0.01) per mm closer to the WMH in the perilesional zones. Lower CBF values correlated with higher leakage measures in the NAWM and WMH …
Scholar articles
SM Wong, JFA Jansen, CE Zhang, EI Hoff, J Staals… - Neurology, 2019