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REVIEW intricate molecular topologies and architectures. To turn the molecular dreams into a reality, synthetic chemists must ultimately roll up their sleeves and become molecular construction workers building their structure brick by brick. From the dawn of the modern chemistry in the ages of Boyle, Dalton, and Lavoisier to the present days, the tools for molecular construction have evolved, progressing through notable paradigm shifts from the development of the atomistic theory to the rigorous application of the retrosynthetic method focusing on the enantioselective synthesis of medicinal natural products. 1-3 More recently, academic and industrial focus has moved toward efficient chemistry utilizing low-cost and green reagents in transformations designed with high atom-economy starting from biosourced feedstocks as well as beyond the small molecule in strategies to produce designed macromolecular …