Authors
Christine Bernsmeier, Oltin T Pop, Arjuna Singanayagam, Evangelos Triantafyllou, Vishal C Patel, Christopher J Weston, Stuart Curbishley, Fouzia Sadiq, Nikhil Vergis, Wafa Khamri, William Bernal, Georg Auzinger, Michael Heneghan, Yun Ma, Wayel Jassem, Nigel D Heaton, David H Adams, Alberto Quaglia, Mark R Thursz, Julia Wendon, Charalambos G Antoniades
Publication date
2015/3/1
Journal
Gastroenterology
Volume
148
Issue
3
Pages
603-615. e14
Publisher
WB Saunders
Description
Background & Aims
Characteristics of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) include susceptibility to infection, immuneparesis, and monocyte dysfunction. MER receptor tyrosine kinase (MERTK) is expressed by monocytes and macrophages and contributes to down-regulation of innate immune responses. We investigated whether MERTK expression is altered on monocytes from patients with liver failure.
Methods
We analyzed blood and liver samples collected from patients admitted to the liver intensive therapy unit at King’s College Hospital in London from December 2012 through July 2014. Patients had either ACLF (n = 41), acute decompensation of cirrhosis without ACLF (n = 9), cirrhosis without decompensation (n = 17), or acute liver failure (n = 23). We also analyzed samples from healthy individuals (controls, n = 29). We used flow cytometry to determine the level of innate immune …
Scholar articles
C Bernsmeier, OT Pop, A Singanayagam… - Gastroenterology, 2015