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Background and Purpose. Verbal working memory (VWM) deficits have been a well‐replicated finding among patients with multiple sclerosis (MS). Functional magnetic resonance imaging (FMRI) studies have described a VWM system in healthy samples; however, functional neuroimaging of this system among MS patients is just beginning to appear. Methods. Fifteen MS patients and 15 sex‐, age‐, education‐, and IQ‐matched healthy control (HC) participants completed a 2‐Back VWM task as whole‐brain FMRI was conducted. Results. Each group exhibited increased brain activity compared to the 0‐Back control task in regions associated with the 2‐Back in previous neuroimaging studies. These included Broca's area, supplementary motor area (SMA), premotor cortices (PMC), and dorsolateral prefrontal cortices (DLPFC). MS patients exhibited greater cortical activity than did HC participants in left primary motor …