Authors
Grant N Colfax, Glenn-Milo Santos, Moupali Das, Deirdre McDermott Santos, Tim Matheson, James Gasper, Steve Shoptaw, Eric Vittinghoff
Publication date
2011/11/7
Journal
Archives of general psychiatry
Volume
68
Issue
11
Pages
1168-1175
Publisher
American Medical Association
Description
Context
No approved pharmacologic treatments for methamphetamine dependence exist. Methamphetamine use is associated with high morbidity and is a major cofactor in the human immunodeficiency virus epidemic among men who have sex with men (MSM).
Objective
To determine whether mirtazapine would reduce methamphetamine use among MSM who are actively using methamphetamine.
Design
Double-blind, randomized, controlled, 12-week trial of mirtazapine vs placebo conducted from September 5, 2007, to March 4, 2010.
Setting
San Francisco Department of Public Health.
Participants
Participants were actively using, methamphetamine-dependent, sexually active MSM seen weekly for urine sample collection and substance use counseling.
Interventions
Random assignment to daily oral mirtazapine (30 mg) or placebo; both arms included 30-minute weekly substance use counseling.
Main Outcome …
Total citations
Scholar articles
GN Colfax, GM Santos, M Das, DMD Santos… - Archives of general psychiatry, 2011