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A nanostructured signal-responsive thin hydrogel membrane was coupled with enzyme-based systems to yield “smart” multisignal-responsive hybrid systems with built-in “logic”. The enzyme systems transduce biochemical input signals into structural changes of the membrane, thus resulting in the amplification of the biochemical signals and their transformation into the gated transport of molecules through the membrane. Coupling of the biocatalytic systems with a stimuli-responsive membrane is a promising approach for the development of materials that can regulate transport and release of chemicals/drugs by receiving and processing the biochemical information via biochemical reactions.