Autores
Elena López-Isac, Marialbert Acosta-Herrera, Martin Kerick, Shervin Assassi, Ansuman T Satpathy, Jeffrey Granja, Maxwell R Mumbach, Lorenzo Beretta, Carmen P Simeón, Patricia Carreira, Norberto Ortego-Centeno, Ivan Castellvi, Lara Bossini-Castillo, F David Carmona, Gisela Orozco, Nicolas Hunzelmann, Jörg HW Distler, Andre Franke, Claudio Lunardi, Gianluca Moroncini, Armando Gabrielli, Jeska de Vries-Bouwstra, Cisca Wijmenga, Bobby PC Koeleman, Annika Nordin, Leonid Padyukov, Anna-Maria Hoffmann-Vold, Benedicte Lie, Susanna Proudman, Wendy Stevens, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG) Zochling J. 66 Sahhar J. 67 Roddy J. 68 Nash P. 69 Tymms K. 70 Rischmueller M. 71 Lester S. 71, Timothy Vyse, Ariane L Herrick, Jane Worthington, Christopher P Denton, Yannick Allanore, Matthew A Brown, Timothy RDJ Radstake, Carmen Fonseca, Howard Y Chang, Maureen D Mayes, Javier Martin
Fecha de publicación
2019/10/31
Revista
Nature communications
Volumen
10
Número
1
Páginas
4955
Editor
Nature Publishing Group UK
Descripción
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work …
Artículos de Google Académico
E López-Isac, M Acosta-Herrera, M Kerick, S Assassi… - Nature communications, 2019