Autores
Gisela Orozco, Behrooz Z Alizadeh, Angélica M Delgado‐Vega, Miguel Á González‐Gay, Alejandro Balsa, Dora Pascual‐Salcedo, Benjamín Fernández‐Gutierrez, María F González‐Escribano, Ingemar F Petersson, Piet LCM Van Riel, Pilar Barrera, Marieke JH Coenen, Timothy RDJ Radstake, Miek A Van Leeuwen, Cisca Wijmenga, Bobby PC Koeleman, Marta Alarcón‐Riquelme, Javier Martín
Fecha de publicación
2008/7
Revista
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
Volumen
58
Número
7
Páginas
1974-1980
Editor
Wiley Subscription Services, Inc., A Wiley Company
Descripción
Objective
This study was undertaken to investigate the previously reported association of the STAT4 polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls.
Methods
Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Spain, 273 RA patients and 285 healthy controls from Sweden, and 876 RA patients and 893 healthy controls from The Netherlands. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the STAT4 single‐nucleotide polymorphism rs7574865 using a TaqMan 5′‐allele discrimination assay. The chi‐square test was performed to compare allele and genotype distributions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
Results
We observed a …
Citas totales
Artículos de Google Académico
G Orozco, BZ Alizadeh, AM Delgado‐Vega… - Arthritis & Rheumatism: Official Journal of the American …, 2008