Autores
José Luis Caro-Oleas, María Francisca González-Escribano, Francisco Manuel González-Roncero, María José Acevedo-Calado, Virginia Cabello-Chaves, Miguel Ángel Gentil-Govantes, Antonio Núñez-Roldán
Fecha de publicación
2012/3/1
Revista
Nephrology Dialysis Transplantation
Volumen
27
Número
3
Páginas
1231-1238
Editor
Oxford University Press
Descripción
Background
Clinical relevance of donor-specific antibodies (DSAs) detected by a single antigen Luminex virtual crossmatch in pre-transplant serum samples from patients with a negative cytotoxicity-dependent complement crossmatch is controversial. The aim of this study was to analyse the influence of a pre-transplant positive virtual crossmatch in the outcome of kidney transplantation.
Methods
A total of 892 patients who received a graft from deceased donors after a negative cytotoxicity crossmatch were included. Presence of anti-human leucocyte antigen (HLA) antibodies was investigated using a Luminex screening assay and anti-HLA specificities were assigned performing a Luminex single antigen assay.
Results
Graft survival was significantly worse among patients with anti-HLA DSA compared to both patients with anti-HLA with no DSA (P = 0.001 …
Citas totales
Artículos de Google Académico
JL Caro-Oleas, MF González-Escribano… - Nephrology Dialysis Transplantation, 2012